According to the importance of the issue that knowledge and commercialization are highly effective on the progress and industrialization of countries, and considering the lack of proper utilization of scientific achievements and intellectual properties (including inventions, know-how, the development of software, etc.) in Iran due to the existence of barriers, the current study tries to identify and prioritize the existing barriers to the commercialization of scientific achievements in the country and to suggest recommendations for resolving them. For this purpose, first, the variables to measure these obstacles were extracted using the research literature review and interview with managers and experts and prepared in the form of a questionnaire. After confirmation of questionnaire validity and reliability, the questionnaire was distributed among statistical population. Then the data obtained from the questionnaire were analyzed. Finally, the results obtained
from the current research showed that poor communication between universities and industry, shortage of research income for researchers, lack of proper physical resources for research and lack of attention to the criterion of meritocracy in the selection of science and technology managers, are the most important barriers in cultural, human, financial and physical, managerial and structural dimensions, respectively. In the following, some suggestions to resolve such obstacles .are also presented.